C5269

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C5269

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Clindamycin hydrochloride

Synonym:(7S)-7-Chloro-7-deoxylincomycin hydrochloride, Cleocin
CAS Number:21462-39-5
Linear Formula:C18H33ClN2O5S · HCl
Molecular Weight:461.44
Beilstein Registry Number:4070786
EC Number:244-398-6
MDL number:MFCD07793327
PubChem Substance ID:24892772

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Description

Frequently Asked QuestionsLive Chat and Frequently Asked Questions are available for this Product.
Analysis NoteActual content on label
Biochem/physiol ActionsSpectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.
Mode of Action: Inhibits protein synthesis in bacteria by binding the 50s ribosomal subunit.
Clindamycin is a semi-synthetic, lincosamide antibiotic that is prepared from lincomycin. It inhibits bacterial protein synthesis by hydrogen bond interactions with the 23S rRNA component of the 50S ribosomal subunit thus inducing dissociation of the peptidyl-t-RNA complex.
Other NotesAntibacterial and antiprotozoal antibiotic of the licosamide class.

Properties

total impurities≤2 mol/mol EtOH
storage temp.2-8°C

Safety

Hazard CodesXi
Risk Statements36/37/38
Safety Statements26-36
WGK Germany1
RTECSGF2275000

References

referenceSpizek, J., and Rezanka, T., Lincomycin, clindamycin and their applications. Appl. Microbiol. Biotechnol. 64, 455-464, (2004)
 Tenson, T., et al., The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. J. Mol. Biol. 330, 1005-1014, (2003)
 Kouvela, E.C., et al., Unraveling new features of clindamycin interaction with functional ribosomes and dependence of the drug potency on polyamines. J. Biol. Chem. 281, 23103-23110, (2006)
 Cullmann,W., et al., Antibacterial activity of oral antibiotics against anaerobic bacteria. Chemotherapy 39, 169-174, (1993)
 Leigh, D.A., Antibacterial activity and pharmacokinetics of clindamycin. J. Antimicrob. Chemother. 7 Suppl. A, 3-9, (1981)